Journal of Cell Signaling
Open Access
ISSN: 2576-1471
ISSN: 2576-1471
The Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA
"Cardiovascular Disease solving, Wake Forest University School of Medicine, 1996. Hypertension management, Physiology and Pharmacology studies, Hypertension and Vascular Research Center and Cardiovascular Sciences Center and research
Research Article
The Microbiome Product Urolithin A Abrogates the TGF-β-EGFR-PAI-1 Pathway in NRK-52e Renal Epithelial Cells
Author(s): Chappell MC*, Pirro NT, Melo AC, Tallant EN and Gallagher PE
Ellagitanins are natural and complex polyphenolic compounds enriched in foods and commercial supplements. They are initially hydrolyzed to ellagic acid and further metabolized to urolithins by the gut microbiome. Ellagitanins are among a number of endogenous compounds found in fruits, nuts and vegetables that comprise a cardio protective diet for humans; however, biotransformation to urolithins may underlie their protective effects. Chronic treatment with urolithin A conveys anti-fibrotic and anti-inflammatory actions in experimental models of brain, cardiac, and kidney injury. Since the cellular actions and signaling events of urolithin A are undefined in renal cells, we assessed the influence of urolithin A on the TGF-β-PAI-1 pathway in NRK-52e cells, a well-characterized model of the proximal tubule epithelium and TGF-β induced signaling. TGF-β stimulated PAI-1 relea.. View More»
DOI:
10.35248/2576-1471.20.5.204