Journal of Nutrition & Food Sciences
Open Access

Thad Cochran Research Center West, The National Center for Natural Products Research, Oxford, MS, USA

Biography

Charles R. Yates, The National Center for Natural Products Research, Oxford, MS, USA; International experience includes various programs, contributions and participation in different countries for diverse fields of study.

Publications

• Research Article   
  Development and application of an LC-MS/MS method for determining methylsulfonylmethane (MSM) levels in human plasma
  Author(s): Ling Lin, Dejian Ma, Richard J. Bloomer, Matthew Butawan, Webb A. Smith and Charles R. Yates*
  
  Methylsulfonylmethane (MSM) isan organosulfur phytochemical widely used as a dietary supplement carrying structure/function claims that includethe promotion of joint health. Untargeted metabolomics studies using nuclear magnetic resonance (NMR) have identified MSM in plasma and urine. However, MS-based methodology is more suitable for pharmacokinetic studies designed to explore MSM’s concentration-effect relationship for purposes of establishing dosing guidelines. To address this deficiency, an LC-MS/MS method using MSM, deuterated MSM (MSM-d6, internal standard), and liquid-liquid extraction was developed and validated in accordance with international guidelines. The method proved well-suited for determining MSM levels in human plasma following chronic oral administration (1, 2, or 3 grams daily) for four weeks. The availability of a robust LC-MS/MS method and MSM dose linearit.. View More»
  DOI: 10.35248/2155-9600.20.10.1000773

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