Journal of Glycobiology
Open Access
ISSN: 2168-958X
+44 1478 350008
ISSN: 2168-958X
+44 1478 350008
Department of Cell Biology and Genetics, Environment and Genes Related to Diseases Key Laboratory of, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, P.R. China
Dr. Chen Huang is currently working as a Principal Investigator at Xi'an Jiaotong University. Author’s significant publications include “Increased Sialylation of N- and O-Glycans on Serum Maackia amurensis Lectin II Binding Glycoproteins in Autistic Spectrum Disorder”. Author current research interests include Glycoproteins , N-glycans, O-glycans, Sialylation, Autistic Spectrum Disorder.
Research Article
Increased Sialylation of N- and O-Glycans on Serum Maackia amurensis Lectin II Binding Glycoproteins in Autistic Spectrum Disorder
Author(s): Yannan Qin, Yanni Chen*, Ganglong Yang, Lingyu Zhao, Zhuoyue Shi and Chen Huang*
Background: The pathophysiology of Autistic Spectrum Disorder (ASD) is not fully understood and there are no diagnostic or predictive biomarkers. In our previous study we found that expression of serum Siaα2-3 Gal/ GalNAc recognized by Maackia amurensis Lectin II (MAL-II) as well as MAL-II Binding Glycoproteins (MBGs) were significantly increased in ASD compared to Typically Developing (TD) children; however the specific glycoforms of MBGs remain unclear.
Method: In this study, N- and O-glycans on sera MAL-II binding glycoproteins (MBGs) from 60 children with ASD and 60 age-matched TD children were profiled by using lectin-magnetic particle conjugate assisted MALDI-TOF/ TOF-MS analysis.
Results: A total of 16 representative N-glycans including high-mannose, complex and hybrid, bi-/tri-antennary structures and bisec.. View More»