Journal of Research and Development
Open Access

University of Verona, Italy

Publications

• Extended Abstract   
  Endoplasmic Reticulum Stress, Inflammation, Oxidative Stress and Neutrophil Extracellular Traps in Cardiovascular Diseases
  Author(s): Chiara Mozzini
  
  The aim of this work is to summarize the understanding of the interrelated roles of endoplasmic reticulum (ER) stress, oxidative stress & inflammation in cardiovascular diseases. Insults interfering with ER function lead to the accumulation of unfolded & misfolded proteins in the ER. An excess of proteins folding in the ER is known as ER stress. This condition initiates the unfolded protein response (UPR). When the UPR fails to control the level of unfolded & misfolded proteins, ER-initiated apoptotic signalling is induced. Moreover, the role of the protective nuclear erythroid-related factor 2 (Nrf2)/antioxidant-related element (ARE) & the activation of the pro-inflammatory nuclear factor-kappa B (NF-kB) are analysed. Current literature d.. View More»
  

  Abstract PDF