Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
+44 1300 500008
ISSN: 2157-7013
+44 1300 500008
Department of Genitourinary, Medical Oncology University of Texas MD Anderson Cancer Center, 1155 Pressler Street Houston, TX 77030-372, United States
Christopher J. Logothetis, M.D., has four decades of research experience, of which the last 25 years have been largely focused on prostate cancer. His focus has been on developing therapies for prostate cancer and linking the underlying biology to the disease. He's contributed to developing chemotherapy, bone targeted therapy and molecularly-targeted therapies in specific subsets of patients in combination.
Review Article
Application of a Successful Germ Cell Tumor Paradigm to the Challenges of Common Adult Solid Cancers
Author(s): Shi-Ming Tu*, Matthew Campbell, Amishi Shah and Christopher J. Logothetis
When we aspire to cure cancer, we may need to search no further than a curable cancer, such as Germ Cell Tumor of
the Testis (TGCT). After all, a germ cell is a primordial stem cell. Importantly, TGCT provides a classic stem cell
model of cancer that teaches us some invaluable lessons about curing other intractable solid tumors.
The intrinsic intratumoral heterogeneity of TGCT alludes to its stem-ness origin and nature. Which implicates the
existence of putative lethal TGCT subtypes-the identification and detection of which may further enhance the cure
rate and improve the therapeutic ratio of TGCT
In this Mini review, we discuss about the role of biologic insights, clinical lessons, and therapeutic strategies in drug
and therapy development. We illustrate some clinical pearls and perils when it concerns drug versus therapy
development in the cure and.. View More»
DOI:
10.35248/2157-7013.21.12.301