Chemotherapy: Open Access
Open Access

Department of Dermatology, Hunan Women and Children's Hospital, Changsha, 410000, China

Publications

• Research Article   
  Deciphering Molecular Underpinnings and Therapeutic Avenues for Eczema and Atopic Dermatitis through Integrated Omics and Immunohistochemical Analysis
  Author(s): Fang Yang*, Cong Lin and Youcai Yan
  
  Objective: This study aims to comprehensively explore the comorbidity mechanisms of eczema and Atopic Dermatitis (AD) through the integrated application of Weighted Gene Co-Expression Network Analysis (WGCNA), machine learning, and bioinformatics methods. The goal is to identify potential therapeutic targets and provide a profound understanding of these two skin conditions. Methods: We conducted Weighted Gene Co-Expression Network Analysis (WGCNA) and Differential Gene Expression (DEGs) analysis using the Gene Expression Omnibus (GEO) databases GSE6012, GSE14550, GSE32924, and GSE120721. By intersecting the results, we identified 22 genes that are commonly expressed in eczema and atopic dermatitis. Functional enrichment analyses, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), disease prediction, and Protein-Pro.. View More»
  DOI: 10.35248/2167-7700.24.12.225

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