Journal of Sleep Disorders & Therapy
Open Access

Department of Family Medicine, University of British Columbia, Vancouver, Canada

Publications

• Research Article   
  Alzheimer’s Disease: Electroencephalographic Evidence as a Marker of Neurodegeneration
  Author(s): Dina Rodinskaia* and Crystal Radinski
  
  Background: Progressive deterioration of synaptic plasticity and synaptic connectivity between neurons is a neurophysiological hallmark of brain ageing and has been linked to the severity of dementia. We hypothesized that if synaptic disconnection as the neuropathology of Alzheimer’s Disease (AD) is responsible for the failure of the brain to integrate various regions into effective networks, then electroencephalographic evidence of the disruption of functional connectivity might be used to diagnose Alzheimer’s dementia. We proposed that changes in Electroencephalogram (EEG) coherence, a measure of functional interaction between the brain collaborating areas, can be detected in a clinical setting and serve as a marker of neuronal disconnection. Improving the accuracy and reducing the time needed to diagnose AD could allow timely interventions, treatments, .. View More»
  DOI: 10.35248/2167-0277.22.11.375

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