Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Department of Non-clinical Efficacy Assessment, AtoGen Company Research institute, AtoGen. Co., Ltd., Daejeon, Republic of Korea
Research Article
Lactobacillus reuteri ATG-F4-Mediated Amelioration of Muscle Atrophy: Role of Gut Microbiota Composition and Short-Chain Fatty Acids
Author(s): Daeyoung Lee*, Young-Sil Lee, Gun-Seok Park, Juyi Park, Seung-Hyun Ko, You-Kyung Lee, Do Yeun Jeong, Yong Hyun Lee and Jihee Kang
Probiotics offer a promising avenue for combating muscle atrophy, a debilitating condition associated with disuse,
aging and disease. This study investigated the anti-atrophic potential of Lactobacillus reuteri ATG-F4, a human gutderived
bacterium, in a staple-induced immobilization mouse model. ATG-F4 administration significantly preserved
muscle mass and improved grip strength and endurance, compared to disused controls. Mechanistically, ATG-F4
activated mammalian Target of Rapamycin (mTOR) signalling, promoting protein synthesis, while downregulating MuRF1, a key atrophy factor. Furthermore, ATG-F4 treatment demonstrably altered the gut microbiota composition,
favoring the Muribaculaceae family and decreasing Lachnospiraceae and Lactobacillaceae. This regulation suggests that
it may increase serum levels of the Short-Ch.. View More»
DOI:
10.35248/2329-8901.24.12.349