Journal of Clinical Trials
Open Access

Department of Gastroenterology, ProgenaBiome, Ventura, California, United States

Publications

• Research Article   
  Impact of Probiotics on Gut Microbiome Bifidobacterium Relative Abundance: First Do No Harm
  Author(s): Daniels Jordan*, Papoutsis Andreas, Barrows Brad and Hazan Sabine
  
  Background: Several reports have raised safety concerns regarding the use of probiotics. To address these concerns, this study examined the relative abundance (proportion of the microbiome made up of a particular taxa) and normalized read counts (number of times a particular microbe was identified) of Bifidobacteria in the gut microbiome of healthy subjects participating in an ongoing study on the microbiome. Bifidobacteria is a critically important constituent of the human microbiome and plays roles in digestion, gut immunity, and cancer prevention. Methods: Fecal samples were analyzed using next-generation sequencing to evaluate composition and relative abundance of bacterial phyla through species level in each subject`s microbiome. The primary outcomes of this subgroup analysis were relative abundance and.. View More»
  DOI: 10.35248/2167-0870.21.11.473

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