Immunome Research
Open Access

Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy

Biography

Darja Kanduc is from department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy. His research interests in study of life and living organisms, their life cycles, adaptations and environment

Publications

• Research   
  SARS-CoV-2 and Autoimmunity: From Myocarditis to Arrhythmia and Cardiac Death
  Author(s): Darja Kanduc*
  
  Background: Clinical attention has focused recently on an unexplained insurgence of Cardiovascular Diseases (CVDs) in concomitance with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Here, this study aimed at defining the possible role of autoimmune cross-reactivity and immunologic memory as mechanisms that might link the viral infection to CVDs. Methods: Human proteins that, when altered, associate with CVDs were searched for pentapeptide immune determinants that are shared with SARS-CoV-2 spike glycoprotein (gp) and also recur in common pathogens to which the general population is frequently exposed. Results: Comparative sequence analyses show that: 1) a high level of peptide sharing exists between SARS-CoV-2 spike gp and human proteins related to CVDs; 2) the shared peptides are endowed with an immunolog.. View More»
  

  Abstract PDF