Journal of Down Syndrome & Chromosome Abnormalities
Open Access

Department of Cardiology, University of Sydney, Sydney, Australia

Publications

• Case Report   
  Sinus Node Dysfunction in People having Down Syndrome with Structurally Normal Hearts: A Case Report
  Author(s): Verity Chadwick, Caroline Medi, Mark McGuire, Ali Sepahpour, Paolo D’Ambrosio, David S Celermajer and Rachael Cordina*
  
  Down Syndrome (DS) is the most common chromosomal abnormality in live born infants. Although limited research suggests that autonomic dysfunction may be more common in the setting of DS, a predisposition to cardiac conduction abnormalities is not well recognized. We performed a retrospective review of records at our tertiary referral centre from Jan 2018 to Jan 2021 to identify people who had Down’s syndrome and required permanent pacemaker implantation for cardiac conduction disease. Inclusion criteria were age ≥ 18 years, and without a structural cardiac abnormality. Three individuals were identified aged between 41 and 59 years; two were female and one was male. All presented with recurrent syncope with sinus pauses (2-10 seconds) identified on Holter monitor (n=2) or loop recorder (n=1). All three patients underwent dual chamber permanent pacemaker in.. View More»
  DOI: 10.35248/2472-1115.23.9.215

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