Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Biomedical Sciences, University of Ostrava, Ostrava, Czech Republic
Research Article
Biochemical Markers of Differentiation of the Inflammatory Process in Synovial Fluid
Author(s): Iveta Bystroňová, Pavlína Kušnierová*, Pavel Walder, Rudolf Hlubek and David Stejskal
Joint infections with non-specific presentation are still difficult to diagnose. We sought to identify biochemical markers in Snovial Fluid (SF) that can predict susceptibility to ongoing inflammatory processes in the joint cavity. Ninety-two consecutive patients were divided into four SF groups based on clustering analysis: non-inflammatory SF (73%), inflammatory-non-pyogenic (12%), inflammatory-pyogenic (10%), or hemorrhagic (5%). We measured and compared the levels of the following biochemical markers in SF: glucose, lactate, total protein, uric acid, C-Reactive Protein (CRP), Leukocyte Count (WBC), Mononuclear (MNP), Polymorphonuclear (PMN), Interleukin (IL)-1 beta, IL6, Procalcitonin, Presepsin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Human Neutrophil Defensin 1-3 (HNP1-3), Cartilage Oligomeric Matrix Protein, Lactoferrin (HLF2), Polymorphonuclear Elastase (PMNE), Matr.. View More»