Lupus: Open Access
Open Access

Department of Medicine, Division of Nephrology and Hypertension, University of Louisville School of Medicine, Kentucky, USA

Biography

Dr. Dawn J Caster belongs from the Department of Medicine, Division of Nephrology and Hypertension, University of Louisville School of Medicine, Kentucky at USA. He specialises in the fields of Biomedical Sciences, medicine,  Health , Medical science, life biology. He published more than 10 articles in different scientific journals and magazines.

Publications

• Short Communication   
  Precision Targeting of NF-kB Signaling in Lupus Nephritis
  Author(s): Dawn J. Caster and David W. Powell*
  
  Lupus Nephritis (LN) is the leading cause of morbidity and mortality from Systemic Lupus Erythematosus (SLE) and enhanced activation of the transcription regulator nuclear factor kappa B (NF-κB) is implicated as a central player in the development and progression of LN. SLE and LN are proposed to develop through a “two-hit” process of genetic mutation or variants providing susceptibility to disease provoking molecular events in response to environmental triggers (viral infection, medication, etc.). Many of the susceptibility genes identified in association with LN are involved in NF-κB regulation and loss of function of some of the protein products in animal’s results in protection from or development of SLE and LN phenotypes. This short commentary will discuss these factors and implications in precision treatment of LN... View More»
  

  Abstract HTML PDF