ISSN: 2169-0111
+44 1478 350008
SplicinagCodes, BioTailor Inc, Miami, United States
Research Article
The Hereditary Fusion Genes are Associated with the Inheritance of Acute Myeloid Leukemia
Author(s): Ling Fei, Jinfeng Yang, Noah Zhuo and Degen Zhuo*
Fusion genes had been thought to be somatic and cause cancer, including Acute Myeloid Leukemia (AML).
Validating highly-recurrent fusion genes in healthy samples compelled us to systematically study Hereditary Fusion
Genes (HFGs). Here, we used the previously-curated 1180 HFGs from Monozygotic (MZ) twins to analyze total fusion
transcripts from AML patients and identified 926 (78.5%) HFGs overlapped with AML. We selected 242 HFGs
ranging from 10% to 83.3% to perform comparative analysis and showed that 239 HFGs were significantly higher
than their counterparts of Genotype-Tissue Expression (GTEx) blood samples and associated with AML inheritances.
A 5’-gene and 3’-gene were fused with multiple 3’-genes and 5’-genes, respectively, to form biological networks and
result in potential hyper susceptibility to somatic genetic and environmental ab.. View More»
DOI:
10.35248/2169- 0111.23.12.214