Journal of Clinical Toxicology
Open Access

Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tirupati, Andhra Pradesh, India

Publications

• Research Article   
  Evaluation of Cytoprotective and In vivo Anti-Oxidant Activity of Argyreia Nervosa Leaves Extract against Hydroquinone Induced Genotoxicity
  Author(s): Divya O*, Pushpakumari B, Anil Kumar D, Nihafiaz S and Sameer P
  
  Hydroquinone (HQ) is a major benzene metabolite, which is produced after benzene biotransformation mainly in liver, lungs and bone marrow. However, the effects of mechanisms, in particular related to its genotoxicity in humans are not well understood. Argyreia nervosa (AN) is traditionally used in rheumatic, cerebral disorders, syphilis, and wound healing as immunomodulatory agent. The aim of this study was to access the protective effect of quercetin present in hydroalcoholic extract of Argyreia nervosa leaves against HQ-induced genotoxicity in rats and to identify and clarify the mechanisms, using albino rats of wistar strain bone marrow cells. The data suggested that HQ caused DNA strand breaks, DNA Protein Crosslink’s (DPC) and chromosomal breaks and significant increase in the frequency of micronuclei was found in the Micronucleus Test (MNT).. View More»
  

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