Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
University Hospital Prof Polydoro Ernani de São Thiago, Federal University of Santa Catarina - HU/UFSC/EBSERH, Florianópolis, Brazil
Research Article
Efficacy of the Measles-Mumps-Rubella (MMR) Vaccine in the Reducing the Severity of Covid-19: An Interim Analysis of a Randomised
Controlled Clinical Trial
Author(s): Edison Natal Fedrizzi*, Juliana Balbinot Reis Girondi, Thiago Mamoru Sakae, Sérgio Murilo Steffens, Aldanéa Norma de Souza Silvestrin, Grace Serafim Claro, Hugo Alejandro Iskenderian, Bianca Hillmann, Liliam Gervasi, Alberto Trapani Junior, Patricia de Amorim Rodrigues, Amanda de Souza Vieira, Scheila Monteiro Evaristo, Francisco Reis Tristão, Fabiano da Silva Muniz, Maria Veronica Nunes, Nicole Zazula Beatriz, Jhonathan Elpo, Amanda Tiedje, Louise Staudt Siqueira, Marilin Sens, Vitor Nandi, Jessica Goedert Pereira, Gustavo Costa Henrique, Ana Paula Fritzen de Carvalho, Ramon Carlos Pedroso de Morais, Gustavo Giorgio de Cristo, Maria Eduarda Hochsprung, Ana Cristina Morais, Rubens Centenaro, Andrez Garcia, Marcelo da Silva Fedrizzi, Bettina Heidenreich Silva, Eluze Luz Ouriques Neta, Maria Eduarda Alves Ferreira, Maria Eduarda Hames, Maria Eduarda Paixão Gubert, Milena Ronise Calegari, Maria Luiza Baixo Martins, Geovana Samuel Oliveira, Marilia de Souza Marian and Larissa Sell Sousa
Background: COVID-19 is still a challenge, both with regard to its treatment and to the actual efficacy of the vaccines available to date, especially with the emergence of new variants. We evaluated the efficacy of the Measles-Mumps- Rubella (MMR) vaccine in preventing SARS-CoV-2 infection and severity of COVID-19 in health workers.
Methods: This analysis includes data from one ongoing blinded, randomized, placebo-controlled trial with participants aged 18-60 years were randomly assigned to receive the MMR vaccine or a placebo. The primary efficacy analysis included all participants with a positive nasopharyngeal RT-PCR test since their inclusion.
Results: The MMR vaccine did not prevent the SARS-CoV-2 infection. Participants in the MMR group, compared with those in the placebo group, had a 48% risk reduction in sy.. View More»
DOI:
10.35248/2167-0870.22.S15.004