Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Department of Pharmacology, Fayoum University, Fayoum, Egypt
Research Article
Prebiotics and Probiotics: New Adjuvant Therapies for Children with Idiopathic Relapsing Nephrotic Syndrome
Author(s): Rehab A. Mohammed*, Sherin Khamis Hussein, Sylvana N. Gaber, Fatma A. Ahmed, Walaa Abdelfattah and Eman S. Said
Background: Idiopathic Nephrotic syndrome (INS) is an autoimmune disease characterized by repeated relapses with
allergic conditions. The etiology remains unknown, new evidence correlates to the dysfunction of T Regulatory cells
(T-Reg) which could be due to gut microbiota dysbiosis.
Aim: To investigate the effect of prebiotics and probiotics as adjuvant therapies for children with relapsing idiopathic
nephrotic syndrome.
Methods: The study was designed as a prospective open label randomized clinical trial; involving 30 children
diagnosed as relapsing NS. Children were randomly divided into two groups, group treated with prednisone only and
group treated with prebiotics and probiotics in addition to prednisone. Fresh stool samples were collected from the
children. Lactobacillus species were i.. View More»
DOI:
10.35248/2572-0775.24.09.269