ISSN: 2475-7586
GE Global Research, Niskayuna, NY, USA
Eric Fiveland Currently working at GE Global Research, Niskayuna, NY, located in USA. MRI engineer and GE Global Research, Engineer, Technician. his research works- Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies, Intrinsic Brain Connectivity in Chronic Pain: A Resting-State fMRI Study in Patients with Rheumatoid Arthritis etc.
Research
Validation of a Novel Noxious Pressure Device for Use in fMRI Pain Studies
Author(s): Marisa DiMarzio, Michael Spinrad, Maria Hancu, Ellinor Grinde, Jamie Chang, Julia Slyer, Michael Gillogly, Julia Prusik, Julie G. Pilitsis*, Eric Fiveland and Ileana Hancu
Background: Most fMRI studies on pain perception utilized thermal stimuli due to the lack of a non-metallic reliable, reproducible mechanical stimulus. We explored 2 potential MR compatible mechanical devices and validated one that induced changes on fMRI.
Purpose: To validate a noxious mechanical stimulus MR compatible device in a healthy cohort and a chronic pain cohort. Further to ensure this device caused changes on fMRI compared to a pressure device.
Methods: Two-healthy controls underwent fMRI scans in the presence/absence of mechanical noxious stimuli using different devices. A paradigm for administering the stimuli with the most robust responses on fMRI was developed. Reproducibility of the device was confirmed in 10 chronic pain patients and age/gender-matched healthy controls. Comparisons of patient demog.. View More»
DOI:
10.35248/2475-7586.19.4.138