Journal of Perioperative Medicine
Open Access

Department of Anesthesiology and Intensive Care, Dr. Hasan Sadikin Central General Hospital, Padjadjaran University, Bandung, Indonesia

Publications

• Research Article   
  The Effect of Preoperative Simvastatin on Heme Oxygenase-1 (HO-1), Plasma NGAL and the Incidence of Post-Operative Acute Kidney Injury in Patient Undergoing Exploratory Laparotomy Surgery
  Author(s): Erwin Pradian*
  
  Background: Stress due to surgical laparotomy causes the release of cytokine and inflammatory mediators which may increase the formation of Reactive Oxygen Species (ROS) and free heme plasma. Free heme plasma acts as a strong oxidant and may damage cells including the kidneys tubules causing Acute Kidney Injury (AKI) marked by an increase of Neutrophil Gelatinase Associated Lipocalin (NGAL). This heme oxidant is neutralized by Heme Oxygenase-1 (HO-1). Simvastatin is known to increase HO-1 gene expression and plasma level. The aim of this research is to determine the effect of preoperative simvastatin on HO-1 and NGAL plasma levels, and the AKI incidents on exploratory laparotomy surgery patients. Methods: This research is a randomized control trial on patients undergoing laparotomy. Following approval from the ethics commi.. View More»
  DOI: 10.35248/2684-1290.22.5.123

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