Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Internal Medicine, Mansoura University, Mansoura, Egypt
Research Article
Il-27 and Il-18 Genes Polymorphism in Egyptian Systemic Lupus
Erythematosus Patients
Author(s): Ehsan Rizk*, Ashraf Mohamed, Abdelnaser Badawy, Naglaa Mokhtar, Eslam Eid, Noha Abdelsalam, Sameh Abdellatif, Mona Balata and Emad Elmasry
Background: Systemic Lupus Erythematosus (SLE) is one of the autoimmune disorders affecting many organs and systems with heterogeneity in clinical manifestations and disease course. Cytokines may play a role in the pathogenesis of the disease.
Objectives: To assess the possible role of the polymorphisms of IL-18 and IL-27 genes in SLE development.
Subjects and methods: A case control study was conducted on 120 patients with SLE and 100 ages-matched healthy individuals considered the control group. The IL-27-924A/G and IL-18-607C/A polymorphisms by RFLP-PCR.
Results: For IL-27 924A/G gene polymorphism, The AA genotype was more frequent in SLE group in comparison to the healthy individuals (P=0.04, OR (95% CI)=2.3(1-5.4). On the other hand, AG genotype frequency was higher in the control gr.. View More»
DOI:
10.35248/JCCLM.22.5.237