Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Center for Clinical Research and Translational Medical, Lianyungang Oriental Hospital, Lianyungang, Jiangsu Province, China
Research
Mechanism of Ozone Alleviation of Malignant Ascites in Hepatocellular Carcinoma through Inhibition of NETS
Author(s): Feng Han, Jiayou Guo, Mingchen Mu, Ka Bian, Zhenting Cui, Qiong Duan, Jianxin Ma*, Lai Jin*, Wentao Liu* and Fanghong Chen*
Malignant ascites in hepatocellular carcinoma is usually a sign of advanced disease and poor prognosis and is also
thought to be associated with chronic inflammation mediated by Neutrophil Extracellular Trap-networks (NETs).
Whereas ozone, a strong oxidant, has significant antibacterial and anti-inflammatory effects, its effectiveness in
treating malignant liver ascites is unclear. cOzone showed significant anti-peritoneal fluid production properties in
H22 tumor-bearing mice, and ozone reduced peritoneal fluid production by activating AMPK and up-regulating
SR-A phagocytosis Damage-Associated Molecular Patterns (DAMPs) to reduce the production of NETs. This
suggests that ozone could be used as a new drug for the treatment of malignant ascites in hepatocellular carcinoma... View More»
DOI:
10.35248/2167-0870.23.13.529