Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, Iran
Research Article
Type 2 Diabetes and its Effects on MicroRNA-155 and MicroRNA-133a Expression in Lung Tissue of Male Rats
Author(s): Maria Khezri, Reza Rahbarghazi, Mahdi Ahmadi, Siamak Sandoghchian, Alireza Nourazarian, Behrouz Shademan, Meysam Abdi and Fatemeh Khaki-Khatibi*
Extensive vascularity and large amounts of collagen and elastin in the lung tissue makes the lung parenchyma
vulnerable to diabetes. However, there are few studies on the pathophysiological effects of diabetes on lung tissue.
Therefore, in this study, we investigated the impacts of Type 2 Diabetes (T2D) on lung tissue pathology and the
expression of miRNA-155 and miRNA-133a in the lung tissue of male rats. In this study, 20 male rats were divided
into a control group and a diabetic group. The diabetic group received a high-fat diet for four weeks. After the
fourth week, the rats were injected with a single dose of Streptozotocin (STZ). Blood glucose and Glucose Tolerance
Tests (GTT) were measured four days after the STZ injection; immediately after testing, rats were sacrificed, and
lung tissue was collected to measure microRNA (miRNA) and examine tissue changes. .. View More»
DOI:
10.35248/JCCLM.23.6.263