Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Biomedical Research Institute, Darfur University College, Nyala, Sudan
Review Article
Epigenetic Modifications in the Endocrine System Organs Cancer
Author(s): Abdelkareem A. Ahmed*, Mohammed Elmujtba Adam Essa, Fathi Abdallah Mohammed and Ayman Sati Sati Mohamed
Abnormal epigenetic modifications are a trademark of cancer, and endocrine system related organs cancers are
without exception. Lately, studies have acknowledged an ever-growing number of epigenetic modifications in both
DNA methylation and histone modifications in the endocrine system organs cancers. Novel ultra-deep sequencing
and microarray technologies have permitted to study the genome-wide epigenetic patterns in some endocrine system
organs cancer types such as parathyroid gland, adrenocortical, and breast carcinomas. However, up till now, in other
types of cancer, such as the multiple endocrine neoplasia syndromes, thyroid cancer, the tumor information is scare
to candidate genes alone. Future research are required to focus in this direction to cover the deepen understanding
of the functional role of these epigenetic modifications in endocrine system cancer.. View More»
DOI:
10.35248/2155-9899.20.11.605