Journal of Cancer Science and Research
Open Access

Department of Animal Biology, Cheikh Anta DIOP University, Dakar, Senegal

Publications

• Research Article   
  Exploring the Role of Non-Coding Sequence Mutations in Breast Cancer
  Author(s): Ramatoulaye Niang*, Fatimata Mbaye and Mbacké Sembeme
  
  Objective: Breast cancer is one of the most common diseases affecting women worldwide. However, mortality rates are disproportionately high among Black women, regardless of incidence rates. Although several factors related to age, steroid hormones, breastfeeding, and genetic aberrations have been implicated, the exact mechanism for this disparity remains unclear. The purpose of this study was to investigate the genetic profile of non-coding DNA sequences and determine their potential impact on breast cancer development. Methods: Tissue samples were obtained from patients at the Joliot-Curie institute in Dakar, Senegal. Using Polymerase Reaction Chain (PCR) and the Sanger method, we sequenced Beta-Fibrinogen (FGB) intron 7 and mitochondrial D-loop region. The nucleotide sequences of both genes were then compared to reference s.. View More»
  DOI: 10.35248/2576-1447.23.8.537

  Abstract HTML PDF