ISSN: 0974-276X
Department of Animal Biology, Genomics Laboratory, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Research Article
Involvement of TP53 Mutations in the Occurrence of Oral Cavity Cancers in Senegalese Patients
Author(s): Mame Diarra Samb*, Fatimata Mbaye, Mouhamadou Makhtar Ndiaye, Malick Fall, Silly Toure and Mbacke Sembene
The Head and neck cancers are a group of heterogeneous tumors, among which oral cavity cancers appear to be increasingly common. It has been reported that solid tumors are not genetically stable; accordingly, identification of the genetic factors involved in oral carcinogenesis could aid in preventing the spread of oral cancers. Therefore, in this study, we aimed to determine the involvement of TP53 mutations in oral cavity cancers in Senegalese patients. Samples from 40 patients with cancer were included in this study. Blood samples were collected from controls. Tissues were collected from each patient during biopsy after obtaining their consent. DNA extraction, polymerase chain reaction, and sequencing were performed to obtain sequences. The chromatograms were compared to the reference sequence using Mutation Surveyor software. In addition, the COSMIC database, Mutation Tas.. View More»
DOI:
10.35248/0974-276X.23.16.635