Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Oncology, The First Clinical College of Nanjing Medical University, Nanjing, China
Research Article
A Novel Signature Based on Crosstalk Between Anoikis and Pyroptosis Associated Genes for Prediction of Clinical Outcomes, Tumor Microenvironment (TME) and Treatment Response of Breast Cancer
Author(s): Qian Liu, Fei Qu, Xue Fang Wu, Rongrong Lu and Wei Li*
Background: Breast cancer is now the most prevalent malignant among female population worldwide. Anoikis is a key progress during genesis and metastasis of malignant cells. Pyroptosis is a newly defined type of programmed cell death reported to have a dual effect on the development of carcinomas and had been reported to have the potential to affect anti-tumor immunity. However, few studies investigated the connections between anoikis, pyroptosis and prognosis in breast cancer.
Methods: Anoikis and Pyroptosis related Genes (APGs) were achieved from GeneCards and Harmonizome portals database. Based on expression profiles of APGs of patients from TCGA-BRCA cohort, differentiated expressed APGs between normal and tumoral tissues are identified. Next, by univariate Cox regression analysis of combined data of TCGA and GSE cohorts, prognostic APGs .. View More»
DOI:
10.35248/2471-9552.23.09.237