Immunotherapy: Open Access
Open Access

Department of Gastrointestinal Surgery, Zaozhuang Municipal Hospital, No 41 Longtouzhong road, Shizhong District, ZaoZhuang City, Shandong Province, 277100, China

Biography

Molecular & Cellular Biology
Baylor College of Medicine
Houston, Texas United States.
BSc from Jilin University
Changchun, Jilin China
PhD from Institute of Biophysics, Chinese Academy of Sciences
Beijing, China
Postdoctoral Training at Baylor College of Medicine
Houston, Texas United States

Publications

• Research Article   
  Comprehensive Analysis of Immune Related Genes in the Tumor Microenvironment of Colorectal Cancer
  Author(s): Deyu Chen, Peng Han and Feng Yang*
  
  Objective: This study was therefore designed to conduct a robust analysis of Colorectal cancer (CRC) immune microenvironment to identify specific genes and pathways that can be targeted in an effort to achieve more effective immunotherapy outcomes. Methods: Using five Independent data sets, we analyzed expression profiles associated with 29 different immune signatures, and we used these profiles to guide the hierarchical clustering of CRC samples based on their immune micro environmental composition Results: We were able to cluster our CRC samples based on whether they had exhibited high, medium, or low levels of infiltration by immune cell types associated with tumor clearance (Immunity-H, Immunity-M, and Immunity-L, respectively). Samples in the Immunity-H subset exhibited a “hot” immune.. View More»
  

  Abstract PDF