Translational Medicine
Open Access

Department of Molecular Pharmacology and Drug Evaluation, Ministry of Education of China, School of Pharmacy, Yantai University, Yantai 264005, P.R. China

Publications

• Research Article   
  Xingnaojing: Improving Neurological Function and Attenuates Intestinal Injury in Intracerebral Hemorrhagic Mice
  Author(s): Ce Zhang, Yiqian Fan, Shumin Yue, Yunqi Yang, Min Li, Tian Wang and Fenghua Fu*
  
  To investigate the effects of Xingnaojing (XNJ) on the impairments of neurological functions and intestinal injury in Intracerebral Hemorrhage (ICH) mice. In vivo, mouse ICH model was prepared with stereotaxic injection of collagenase into the right basal ganglia. ICH mice were treated with XNJ (2.5, 5.0, 10.0 mL/kg intra-venous.). Garcia test and brain edema were evaluated. The Lipopolysaccharide (LPS), TNF-α and IL-1β in both blood and brain were assayed using Enzyme-Linked Immunoassay (ELISA) kits. The intestinal injury was also observed. In vitro, the model of gut injury was established using lipopolysaccharide-challenged Colon Carcinoma-2 (Caco-2) cells. And intestinal injury was evaluated by assaying Transepithelial Electrical Resistance (TEER) and FITC-D4 flux. In vivo, ICH mice exhibited a decrease of Garcia test score and an .. View More»
  DOI: 10.35248/2161-1025.22.12.274

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