Anesthesia & Clinical Research
Open Access

Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil

Publications

• Short Communication   
  Exploiting Ionic Gradient Liposomes for Anesthetic use: The Case of Enantiomeric-Excess Bupivacaine and Etidocaine
  Author(s): Juliana Damasceno Oliveira, Fernando Freitas de Lima and Eneida de Paula*
  
  Commercial products like Exparel® and Bupisome®, which contain bupivacaine, offer prolonged, non-opioid alternatives for the management of post-operative pain. These pharmaceutical products share a common feature: the nanoformulation of the local anesthetic bupivacaine in Ionic Gradient Liposomes (IGL). IGL are specially designed liposomes known for their extensive loading capacity, which allow them to both extend the effectiveness and reduce the toxicity of weak bases such as local anesthetics. We outline here the benefits of two IGL formulations designed specifically for the encapsulation of bupivacaine in its enantiomeric excess form (S75BVC) or Etidocaine (EDC)... View More»
  DOI: 10.35248/2155-6148.23.14.1111

  Abstract HTML PDF