Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Chest Diseases, Selcuk University, Konya, Turkey
Research Article
The Relationship between Disease Diagnosis, Severity and Serum ADMA, SDMA and L-NMMA in Patients with Obsessive Sleep Apnoea Syndrome
Author(s): Emrah Bolca*, Dilek Ergun, Recai Ergun, Fikret Kanat, Ali Unlu, Duygu Eryavuz Onmaz and Muslu Kazim Korez
Background: Recurrent hypoxaemia and reoxygenation in patients with Obstructive Sleep Apnea Syndrome (OSAS) may trigger oxidative stress mechanisms. Oxidative stress alters the activities of enzymes involved in the production of Asymmetric Dimethylarginine (ADMA), Symmetric Dimethylarginine (SDMA) and N-Monomethyl L-arginine (L-NMMA), leading to changes in their amounts. In previous studies, it was observed that intermittent hypoxia and hypoxia-re-oxygenation events increased Nitric Oxide (NO) synthesis by increasing endothelial Nitric Oxide Synthase (eNOS) synthase activity in OSAS patients. In our study, we examined the balance between L-arginine-nitric oxide and L-arginine-methylated arginine metabolites (ADMA, SDMA and L-NMMA) pathways due to intermittent hypoxia in newly diagnosed OSAS patients who have not yet developed OSAS-related complications and which pathw.. View More»
DOI:
10.35248/2167-0870.25.15.577