Journal of Molecular Imaging & Dynamics
Open Access

Department of Oral and Maxillofacial Radiology, Radiology Center, Kagoshima University Hospital, Kag, Japan

Publications

• Editorial   
  Gene expression of the clock gene in moving mice in multiple tissues
  Author(s): Francesco Clerici*
  
  In animals, a master clock in the Supra Chiasmatic Nucleus (SCN) regulates circadian rhythms in physiology and behaviour (SCN). Clock genes play an important role in the expression of cellular circadian rhythms, which are principally controlled by a cell-autonomous molecular feedback loop1. Clock gene expression is not restricted to the SCN, as it can be seen in a wide range of organs. However, outside of the SCN, the expression pattern of clock genes is poorly understood, partly due to a lack of tools for simultaneously monitoring circadian clock gene rhythms in specific tissues and detecting output functions in the absence of physical limitations. The bioluminescent reporter enzyme firefly luciferase (luc) and its substrate D-luciferin (luciferin) have been successfully adapted to whole-body imaging of clock genes in anaesthetized mice using a charge-coupled device (CCD) camera, and.. View More»
  

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