Journal of Nutrition & Food Sciences
Open Access

Unidad de Investigación en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional, Siglo XXI, (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Mexico

Publications

• Research Article   
  Nutritional Recovery and its Effect on Tryptophan-5-Hydroxylases Expression, Cell Number and on Changes Caused by Intrauterine Growth Restriction in the Developing Brain
  Author(s): Gabriel Manjarrez-Gutiérrez*, Jorge Hernández-Rodríguez and José Antonio Mondragón-Herrera
  
  Objective: The aim of this work was to determine whether the changes in tryptophan-5-hydroxylase (TPH) 1 or 2 brain expression caused by intrauterine growth restriction (IUGR) are maintained or return to normal in the nutritionally-recovered undernourished offspring (UNDO) of rats. Methods: The experimental procedure was: Wistar female rats were subjected to a protein-caloric-restricted diet during gestation. At birth, part of the newborn UNDO pups were fed by their own mothers (UNDO Group), and others were fed by normal control mothers to allow their nutritional recovery (NR Group); pups from normal control dams were fed by them (C Group). On days 1, 15 and 21, brainstem tissue, at the level of dorsal raphe nucleus (DRN), was obtained, in order to determine L-tryptophan (L-Trp), serotonin (5-HT) and TPH activity. In addition, TPH 1 or 2 expre.. View More»
  DOI: 10.35248/2155-9600.20.10.1000774

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