Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Cardio-Thoracic Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Research Article
Exercise-Induced Secretion of NT-Pro BNP in Asymptomatic Hypertensive Patients with Type 2 Diabetes Mellitus: An Early Sign of Subclinical Ventricular Dysfunction
Author(s): Nicolae Paun*, Viorel Jinga, Adriana Mihaela Iliesiu, Gabriela Uscoiu, Andrei Capitanescu, Camelia Nicolae and Stefan-Sebastian Busnatu
Background: The association between Hypertension (HTN) and type 2 Diabetes Mellitus (DM) frequently leads to left ventricular Diastolic Dysfunction (DD).
Objective: The main objective of our study was to diagnose Left Ventricular Diastolic Dysfunction (LVDD) in hypertensive and diabetic patients with normal transthoracic echocardiography.
Methods: We aim to test whether DD can readily be unveiled as early as in the subclinical stage in diabetic hypertensive asymptomatic patients, even before echocardiography can do so. We compared the values of NT-pro BNP (as a marker of increased filling pressures) before and after the treadmill stress test, in hypertensive patients with and without Diabetes Mellitus (DM) and normal subjects. All had normal systolic and diastolic functions at rest and after the stress test, accord.. View More»
DOI:
10.35248/JCCLM.23.6.266