Journal of Antivirals & Antiretrovirals
Open Access

Internal Medicine Department, Mansoura University, Mansoura, Egypt

Biography

Gamal Shiha works at Egyptian Liver Research Institute and Hospital (ELRIAH), Sherbin, El Mansoura, Egypt. The authors area research interests includes Infectious diseases, Virology, Medicine. He /she has authored of many research articles/books in the relevent areas.

Publications

• Research Article   
  Cellular Immune Response (CD8+CD38+) in Relation to Hepatitis B Virus DNA Level and HBsAg Quantification in Hepatitis B Patients
  Author(s): Gamal Shiha*, Toson EA, Amira Elbeeh and Abdellatif H
  
  Introduction: Hepatitis B Virus (HBV) infection is a global public health concern. The immune response in HBV represents a key factor in patient outcome. However, the relationship between viral replication and host immune reactivity remains a matter of investigation. Aim: The aim of our study was to investigate whether the cellular immune response of recently diagnosed and treatment naïve chronic hepatitis B(CHB) patients may be influenced by the replicative status of HBV. Towards this aim, the correlation between HBV viral load, HBsAg quantification and peripheral T-cell subpopulations CD8+CD38+. Methods: Proportions and absolute counts of CD8 CD38 T cells were determined using three-color flow cytometry in chronic hepatitis B patients (n=50) and healthy controls (n=35). Chronic hepatitis B patients were regularly .. View More»
  

  Abstract HTML PDF