Journal of Clinical Trials
Open Access

Department of Fluidics University of Michigan, Ann Arbor, Michigan, USA

Publications

• Research Article   
  Use of Packed Red Blood Cell Mechanical Fragility to Indicate Transfusion Outcomes
  Author(s): Tarasev M*, Chakraborty S, Alfano K, Muchnik M, Gao X and Davenport R
  
  Objective: The hypothesis for this study was that packed Red Blood Cell (pRBC) Mechanical Fragility (MF) could be an aggregate in vitro property predictive of transfused pRBC performance in vivo. Various MF values were obtained via MF profiling, based on several variations of testing parameters, using both a “legacy” approach (with a commercial, cam-based vertical bead mill and a spectrophotometer) and a more proprietary approach (with a custom-developed, electromagnetic horizontal bead mill combined with proprietary optics and analysis). Methods: A total of 52 transfusion events in 32 different patients recruited from the University of Michigan were included in this study, with the primary outcome being the change in patient hemoglobin per pRBC unit transfused (adjusted to the patient blood and transfuse.. View More»
  DOI: 10.35248/2167-0870.22.S19.001

  Abstract HTML PDF