Journal of Cell Science & Therapy
Open Access

Department of Cell and Systems Biology, University of Toronto, Toronto, Canada

Biography

Dr. Gashaw Mathieu is a distinguished researcher in the Department of Cell and Systems Biology at the University of Toronto, Canada. His work focuses on the mechanical properties of cells—such as stiffness, elasticity, and viscosity—and their implications for cellular behavior and therapeutic applications. These properties are fundamental to understanding how cells function, interact with their environment, and contribute to various physiological and pathological processes. In his 2024 publication, "Mechanical Properties of Cells: Implications for Cellular Behavior and Therapy," Dr. Mathieu examines how cellular mechanics influence behaviors like migration, division, and adaptation to mechanical stress. He discusses the role of the cytoskeleton—a network of proteins including actin filaments, microtubules, and intermediate filaments—in determining cell stiffness and elasticity. For instance, cancer cells often exhibit decreased stiffness compared to normal cells, which can affect their ability to invade tissues. Dr. Mathieu also explores how the mechanical properties of the cellular microenvironment can influence stem cell differentiation, impacting tissue development and regeneration

Publications

• Perspective   
  Mechanical Properties of Cells: Implications for Cellular Behavior and Therapy
  Author(s): Gashaw Mathieu*
  
  DOI: 10.35248/2157-7013.24.15.476

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