Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Cellular and Immunology, Centre for Liver Research and Diagnostics, Banjara Hills, Hyderabad, Telangana, India
Research Article
Differential Expression Analysis of Natural Killer (NK) Cell Receptor (NKG2D) in Hepatitis C Virus-Infected Chronic Hepatitis and Hepatocellular Patients for the Development of Targeted Immunotherapy
Author(s): Roya Rozati*, Vikram Aiman Ayapati, Gautam Mehdi Ayapati and Aleem Ahmed Khan
Background: Hepatitis C Virus (HCV) infection causes liver cell injury and ultimately results in liver cirrhosis, fibrosis, and further HCC. Despite current treatment strategies using Direct-Acting Anti-virals (DAAs) to treat HCV patients 40% of HCV infection leads to the development of HCC. The Natural killer cells have a crucial role in an immune response against malignant transformation, including hepatocellular carcinoma. As Natural Killer (NK) cells constitute 25%-50% of liver lymphocytes, they have a significant role to play in liver immunity. A positive correlation exists between the number of Natural Killer (NK) cells in the blood and tumor tissues of HCC patients and their survival and prognosis. The NKG2D receptor has a critical role in the Natural Killer (NK) recognition of target cells. Among different mechanisms, Natural Killer (NK) cell-based innate immu.. View More»
DOI:
10.35248/2471-9552.23.09.235