Virology & Mycology
Open Access

Biochemistry Data Analyst, GDS Applied Mathematics BV, Den Haag, Netherlands

Biography

Han Geurdes work for Biochemistry Data Analyst, GDS Applied Mathematics BV, Den Haag, Netherlands with area of intrest in Philosophy of Mathematics, Philosophy of Physical Science, Philosophy of Probability Science, Logic, and Mathematics.
 

Publications

• Review   
  Occurrence of the Slippery Sequence UUUAAAC in the RNA Genome 2 that generates the ORF1ab Protein of SARS-CoV-2
  Author(s): Geurdes H*
  
  In the present brief report we look into the slippery sequence TTTAAAC (in cDNA format) of the ORF1ab protein of SARS-CoV-2. We found a number of TTTAAAC sequences where only one is actively producing a shift-1. There are three other sequences exactly positioned in the read-through of mRNA as the aforementioned. They do not produce a-1 frameshift. There is one position where in addition a pseudoknot occurs but no frameshift. We ask if it is possible to enforce or prevent shifts in TTTAAAC to destroy the ORF1ab derived proteins such as RNA-dependent RNA polymerase and/or 2’-O-ribose methyltransferase. Finally an mRNA polymer repressor of the one single effective frameshift is proposed for further research into a medicinal treatment. Perhaps that there are specific protein repressors... View More»
  DOI: 10.35248/2161-0517.20.9.198

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