Journal of Probiotics & Health
Open Access

Department of Dermatology, Case Western Reserve University, Center for Medical Mycology,University Hospitals Cleveland Medical Center, Cleveland, USA

Biography

Dr. Ghannoum's research is focused on defining the role of the bacteriome and mycobiome (the bacterial and fungal community) in cancer. His expertise in the area of polymicrobial biofilms provides an important area of cancer research in view of the recent association of polymicrobial biofilms in colorectal cancer and Crohn’s disease.

Publications

• Research   
  The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms
  Author(s): Ghannoum M*, Ghannoum A, Hager C, Retuerto M, Isham N and McCormick TS
  
  Aim: To demonstrate the ability of a probiotic supplement (BIOHM) to disrupt pathogenic gastrointestinal biofilms, thus enhancing nutrient absorption. Methods: A filter insert model using Caco-2 cells to mimic an intestinal monolayer was employed to determine the ability of BIOHM to disrupt a mixed species (Candida tropicalis, Escherichia coli and Serratia marcescens) biofilm known to occur in patients with Crohn’s disease. Penetration of vitamin C and casein as representative of vitamins and proteins, respectively, was then measured. Results: Application of BIOHM led to a significant increase in casein penetration through the Caco-2 cell epithelial monolayer in the absence of biofilms (p value<0.0001). Additionally, the combination of mixed species biofilms grown on a Caco-2 cell monolayer with BIOHM filt.. View More»
  DOI: 10.35248/2329-8901.19.7.213

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