Clinical & Experimental Cardiology
Open Access

Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy

Publications

• Research Article   
  Extracellular Matrix Remodeling and Inflammation in Transthyretin Amyloidosis
  Author(s): Alessia Argirò, Giulia Guidotti, Martina Berteotti*, Viola Liberati, Mattia Zampieri, Federico Perfetto, Marco Allinovi, Anna Poggesi, Carlo Di Mario, Rossella Marcucci and Francesco Cappelli
  
  Introduction and objectives: Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is an interstitial disease characterized by extracellular deposition of amyloid fibrils. The purpose of the study was to assess if inflammation and Extracellular Matrix (ECM) markers are altered in ATTR, as already known for light chain amyloidosis. Methods: Fourty-nine patients with ATTR-CM were enrolled in an observational, prospective, cross-sectional, single- center study and underwent clinical, instrumental and biohumoral markers evaluation. The laboratory results were compared to those of an age and sex-matched cohort of 50 patients with sole atrial fibrillation. Results: Mean age was 78 ± 5 years and 83% of patients were men. Forty-two (86%) had acquired ATTR, 7 (14%) had hereditary ATTR. Patients with ATTR-CM presented higher.. View More»
  DOI: 10.35248/2155-9880.24.15.895

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