Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100, Chieti, Italy
Research Article
Prenatal Corticosterone Exposure Alters Glucocorticoid Metabolic Enzyme Eene mRNA Associated with Increased Aggressive Behaviors and Tonic Immobility in Chicken
Author(s): Abdelkareem A Ahmed*, Mohammed Elmujtba Adam Essa, Adriano Mollica, Azzurra Stefanucci, Gokhan Zengin, Hussain Ahmed and Ayman Sati Sati Mohamed
Exposure to excess Glucocorticoids (GCs) during embryonic development influences offspring physiology and
behaviors and induces change in Hypothalamic-Pituitary-Adrenal (HPA) axis genes expression and serotonergic
system in mammals. Whether prenatal corticosterone (CORT) exposure induces similar effects in avian species
remains unclear. In the present study, we injected low (0.2 μg) and high (1 μg) doses of CORT in ovo before
incubation and detected changes in aggressive behavior, Tonic Immobility (TI), HPA axis and 5-hydroxytryptamine
(serotonin) (5-HT) system gene expression on post hatch chickens of different ages. High dose of CORT significantly
(P<0.05) suppressed growth rate, increased the frequency of aggressive behaviors, which was associated with
elevated plasma CORT concentration. Likewise, in ovo injection of CORT significantl.. View More»
DOI:
10.35248/2155-9899.20.11.604