ISSN: 2471-9552
+44 1223 790975
Laboratory of Virology, Institute of Infectious Agents, Laboratory associated with The National Reference Center for Respiratory Infection Viruses, Hospices Civils de Lyon, Lyon, France
Case Report
Immunity to SARS-CoV-2 in a Dialyzed Patient who Developed COVID-19 Twenty Days after the Second Dose of BNT162b2 Vaccine: A Case Report
Author(s): Sabrina Manni*, Laurène Lotte, Antonin Bal, Laurence Josset, Bruno Lina, Mary Anne Trabaud, Gregory Destras, Bruno Pozzetto, Martine Valette, Corinne Passeron, Barbara Seitz-Poslki, Audrey Sindt and Matteo Vassallo
Introduction: End stage kidney disease (ESKD) and cancer have been identified as risk factors for severe and
fatal cases of COVID-19, making vaccination in these patients a priority. Patients suffering from ESKD have a
significantly weaker response to common vaccines than general population. However, humoral and cellular immune
responses after two doses of RNA-based vaccine BNT162b2 (Pfizer–BioNTech) have been poorly explored in this
vulnerable population.
Case presentation: A 69-year-old male patient was followed for ESKD and myeloma treated with Daratumumab. He
developed a severe SARS-CoV-2 pneumonia treated with oxygen supplementation and dexamethasone twenty days
after two doses of BNT162b2 vaccine. Whole genome sequencing found that the virus belonged to the 20I/501Y.V1
clade. A serology draws eight days after t.. View More»
DOI:
10.35248/2471-9552.22.08.192