Journal of Clinical Toxicology
Open Access

Department of Pharmacy, Negelle Health Science College, Guji, Ethiopia

Publications

• Review Article   
  Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction and their Implication in Clinical Management
  Author(s): Gudisa Bereda*
  
  Drug interaction is a pharmacokinetic or pharmacodynamic consequence of medications on each distinctive, which can sequence, along with desiderated outcomes, in de-escalated effectiveness or escalated toxicity. “Drug-drug interaction” is delineated as the pharmacologic or clinical reaction to the administration of a drug conflation that is distinctive from the expected consequences of the dual medications when bestowed lone. Pharmacokinetic interactions happen when a medicine influences the absorption, distribution, metabolism, or excretion characteristics of disparate medicine PK DDIs happen as a sequence of a revamp in the vulnerability to a bestowed dose of lone medication when bestowed with distinctive. Medications that act as inducers or inhibitors of CYP450 enzymes in the enterocyte and hepatocyte perhaps revamp liability by revamping oral bioavailability. Pharmacody.. View More»
  DOI: 10.35248/2161-0495.23.13.539

  Abstract HTML PDF