Gynecology & Obstetrics
Open Access

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Delhi, India

Publications

• Research Article   
  Association of mRNA Expression of Interleukin-6 and Interleukin-10 with Organochlorine Pesticides in Idiopathic Preterm Birth
  Author(s): Deepika Nayan*, Suman S, Guleria K, Suneja A, Sharma T and Banerjee BD
  
  Objectives: India is one of the nation’s leading in number of Preterm Births (PTB), as reported by WHO. Despite extensive research the exact cause of PTB remains elusive. The present study was designed to gain insight into inflammatory genes (proinflammatory IL-6 and anti inflammatory IL-10) and environment (Organochlorine Pesticides-OCPs) interaction in etiopathogenesis of PTB. Methods: Maternal blood and placental tissue samples of PTB cases (n=263) and equal number of term delivery controls (n=263) were collected at the time of delivery. mRNA expression of IL-6 and IL-10 gene was analysed using real-time PCR and OCP levels by gas chromatography. Results: mRNA expression of IL-6 gene (pro inflammatory) was 11.73 folds high in maternal blood and 2.60 folds higher in placental tissue in PTB compared to term b.. View More»
  DOI: 10.35248/2161-0932.22.12.597

  Abstract HTML PDF