Journal of Cell Science & Therapy
Open Access

Department of Cancer Research, University of Chicago, Chicago, United States

Publications

• Research Article   
  Proteomic Evidence for G-CSF Induced Fibrinolysis and Neovascularization
  Author(s): Darwin Eton*, Amelia Bartholomew, Guolin Zhou and Tong-Chuan He
  
  Objective: To verify proteomic evidence for fibrinolysis and Neovascularization (NV) in patients with Chronic Limb Threatening Ischemia (CLTI) treated with a novel cell therapy approach. Methods: Six CLTI patients were treated for one month with filgrastim (Amgen Inc) 10 mcg/kg SQ every 72 hours, and an external Programmed Infra-Geniculate Compression Pump (PCP) for 3 hours a day. Blood was drawn on day 1 (baseline), and on days 15 and 30 (24 hours after the 5th and 10th Filgrastim doses). On each of these days blood was sampled before and after 2 hours of supervised PCP. Serum ELISA was used to measure the concentration of Plasmin, Fibrin Degradation Products (FDP), VEGF-A, Hepatocyte Growth Factor (HGF) and MMP-9. Results: Statistically significant elevation of plasmin and FDP (p<0.001) were consistently measu.. View More»
  DOI: 10.35248/2157-7013.23.14.381

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