Journal of Clinical and Experimental Ophthalmology
Open Access

Institute of Ophthalmology UCL & NIHR Biomedical Research Centre London, UK

Publications

• Research Article   
  Investigation of the Association between the Oral and the Gut Microbiome in Glaucoma
  Author(s): Anne Katrine Toft-Kehler, Jeppe Vibæk, Miriam Kolko* and Gus Gazzard
  
  Objective: Glaucoma is characterized by a progressive degeneration of retinal ganglion cells (RGC) and their axons leading to painless damage of the visual field and finally blindness. The exact pathophysiology of RGC loss remains unknown. Alterations in the microbiome may be linked to neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, possibly due to associated chronic low-grade inflammation. A recent study linked alterations in the oral microbiome and glaucoma. Methods: We investigated the microbiome of salivary and fecal samples in patients with normal tension glaucoma (10), ocular hypertension (11) and controls (11) using a case-control design with 16S rDNA sequencing. Results: For controls, but not the patient groups, salivary and fecal microbiome diver.. View More»
  DOI: 10.35248/2155-9570.20.11.826

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