Annals and Essences of Dentistry
Open Access
ISSN: 0975-8798, 0976-156X
ISSN: 0975-8798, 0976-156X
Department of Biological and Material Sciences, University of Michigan, Ann Arbor, United States
Research Article
Activity of the Antioxidant Enzymes and RUNX2 Expression on Porous Titanium Alloy Scaffolds
Author(s): Lais Morandini Carvalho*, Luana Marotta Reis de Vasconcellos, Elis Andrade Lima Zutin, Elisa Mattias Sartori, Daniela Baccelli Silveira Mendonca, Gustavo Mendonca and Yasmin Rodarte Carvalho
Studies have been directed towards the production of new titanium alloys, aiming replacement of TiAlV alloy in the future. Therefore, many mechanisms related to biocompatibility and chemical characteristics have been studied in the field of implantology, but until now, enzyme defenses against oxidative stress have been underexplored. The objective of this study was to evaluate the activity of the antioxidant enzymes Superoxide Dismutase (SOD) and Catalase (CAT) in porous scaffolds of Ti-6 Aluminium-4 Vanadium, Ti-35 Niobium and Ti-35 Niobium-7 Zirconium-5 Tantalum. Porous titanium alloy scaffolds were prepared by powder metallurgy. Mesenchymal stem cells from mouse femur were used. After 24 hours the cells plated under the scaffolds were analyzed by Scanning Electron Microscopy (SEM). The antioxidant enzymes activity was measured after 72 hours of cell plating and after 3,7 and 14-day.. View More»
DOI:
10.35248/0976-156X.24.16.281