ISSN: 2329-8901
Department of Dermatology, Case Western Reserve University, Center for Medical Mycology,University Hospitals Cleveland Medical Center, Cleveland, USA
Hager C working as PhD scholar in the French National Institute for Agricultural Research loacted in France. Hager C Editorial Board Member of many peer reviewed journals and area of expertise, as an Research Scholar credits with many publications in national and international journals. Hager C committed to highest standards of excellence and it proves through his/her co-authorship of many books.
Research
The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms
Author(s): Ghannoum M*, Ghannoum A, Hager C, Retuerto M, Isham N and McCormick TS
Aim: To demonstrate the ability of a probiotic supplement (BIOHM) to disrupt pathogenic gastrointestinal biofilms, thus enhancing nutrient absorption.
Methods: A filter insert model using Caco-2 cells to mimic an intestinal monolayer was employed to determine the ability of BIOHM to disrupt a mixed species (Candida tropicalis, Escherichia coli and Serratia marcescens) biofilm known to occur in patients with Crohn’s disease. Penetration of vitamin C and casein as representative of vitamins and proteins, respectively, was then measured.
Results: Application of BIOHM led to a significant increase in casein penetration through the Caco-2 cell epithelial monolayer in the absence of biofilms (p value<0.0001). Additionally, the combination of mixed species biofilms grown on a Caco-2 cell monolayer with BIOHM filt.. View More»
DOI:
10.35248/2329-8901.19.7.213