Journal of Clinical Toxicology
Open Access

Department of Biochemistry and Molecular Biology, Basic Medical College, Zhengzhou University, No.100 Science Avenue, Zhengzhou, China

Biography

Dr. Haifeng Zhang currently working in Basic Medical College, Zhengzhou University, No.100 Science Avenue, Zhengzhou, China in the Department of Biochemistry and Molecular Biology his publications are Inhibition of IL-1? Secretion and Mitochondria Respiration by Arsenite which acts on Myocardial Ischemia-Reperfusion Injury

Publications

• Research Article   
  Inhibition of IL-1? Secretion and Mitochondria Respiration by Arsenite which acts on Myocardial Ischemia-Reperfusion Injury
  Author(s): Min Li, Yingwu Mei, Jingeng Liu, Kaikai Fan, Xinyue Gu, Xu Zhang, Jitian Xu, Yuebai Li, Haifeng Zhang, Ge Jin and Yang Mi*
  
  Arsenite (NaAsO2) is a potent toxin that significantly contributes to human pathogenesis. Chronic exposure to arsenite results in various diseases. The physiologically important biological target(s) of arsenite exposure is largely unknown. Here we found that transient sodium arsenite treatment (1) blocks nigericin or Rotenone induced IL- 1β secretion; (2) inhibits mitochondrial respiration with complex I-linked substrate; (3) induces Heme oxygenase-1 (HO-1) in myocardial tissue, (4) attenuates the myocardial ischemia-reperfusion injury in an in vivo model of rats. The causal relationship among these activities needs further investigation... View More»
  DOI: 10.35248/2161-0495.21.11.487

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