Journal of Cancer Research and Immuno-Oncology
Open Access
ISSN: 2684-1266
+44-77-2385-9429
ISSN: 2684-1266
+44-77-2385-9429
Department of Oncolgy, Womed Therapiezentrum Kinderwunsch GmbH, Innsbruck, Austria
Review Article
Identifying Hypoxia and Glycolysis in Chemotherapy- and Radiation-Induced Cardiotoxicity Based on Nuclear Medicine Diagnostic Imaging with 18F-Flurodeoxyglucose - Key Role of Coenzyme Q10 Deficiency in Acquired Mitochondrial Dys
Author(s): Roe Marcin* and Haira Mewcy
Cardiotoxicity is an unwanted side-effect arising from different medications. The term describes a diminution of heart function, affecting especially left ventricular ejection fraction, which can progress to heart failure. Pediatric oncology patients treated with drugs of the anthracycline group, e.g., doxorubicin, can evolve to heart failure patients in adult age. Nuclear medicine imaging of fatty acid oxidation and glycolysis accurately describes normal and altered heart metabolism. The most common finding is a state of cardiac glycolysis, which is reflected by increased uptake of 18F-desoxyglucose (18F-FDG) at a time when fatty acid oxidation is decreased. Glycolysis has recently been recognized as being the result of coenzyme Q10 deficiency as part of adaptation to hypoxia. Low LEVF correlates with impaired fatty acid oxidation. This deficiency can.. View More»
DOI:
10.35248/2684-1266.24.10.195